A facile preparation of (±)-β-hydroxy nitriles and their enzymatic resolution with lipases

被引：32

作者：

Kamal, A ^{[1
]}

Khanna, GBR ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(01)00058-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple and efficient method for the preparation of racemic 4-aryloxy-3-hydroxybutanenitriles is described, Lipase mediated kinetic resolution in organic media was then utilised to effect enantioseparation. Lipases from different sources were screened in the resolution reaction using a number of organic solvents. Enantiomeric excesses of up to 99%, were obtained by employing lipase from Pseudomonas cepacia in di-iso-propyl ether medium. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：405 / 410

页数：6

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