Efficient production of raspberry ketone via 'green' biocatalytic oxidation

被引：40

作者：

Kosjek, B ^{[1
]}

Stampfer, W ^{[1
]}

van Deursen, R ^{[1
]}

Faber, K ^{[1
]}

Kroutil, W ^{[1
]}

机构：

[1] Graz Univ, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria

来源：

TETRAHEDRON | 2003年 / 59卷 / 48期

基金：

奥地利科学基金会;

关键词：

biocatalysis; Rhodococcus ruber; oxidation; hydrogen transfer; raspberry ketone;

D O I：

10.1016/j.tet.2003.10.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the development of a 'green' oxidation method, the transformation of 4-(p-hydroxyphenyl)butan-2-ol (rhododendrol) into 4-(p-hydroxyphenyl)butan-2-one (raspberry ketone) was used as a model reaction. Different lyophilized cells of Rhodococcus spp. have been screened for their ability to perform the desired oxidation. Rhodococcus equi IFO 3730 and R. ruber DSM 44541 were able to use acetone as a hydrogen acceptor in a hydrogen transfer-like process. The oxidation can be performed at substrate concentrations up to 500 g/L. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：9517 / 9521

页数：5

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