Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines

被引：248

作者：

Christie, PJ ^{[1
]}

机构：

[1] Univ Texas, Houston Med Sch, Dept Microbiol & Mol Genet, Houston, TX 77030 USA

来源：

MOLECULAR MICROBIOLOGY | 2001年 / 40卷 / 02期

关键词：

D O I：

10.1046/j.1365-2958.2001.02302.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial conjugation systems are highly promiscuous macromolecular transfer systems that impact human health significantly. In clinical settings, conjugation is exceptionally problematic, leading to the rapid dissemination of antibiotic resistance genes and other virulence traits among bacterial populations. Recent work has shown that several pathogens of plants and mammals - Agrobacterium tumefaciens, Bordetella pertussis, Helicobacter pylori and Legionella pneumophila - have evolved secretion pathways ancestrally related to conjugation systems for the purpose of delivering effector molecules to eukaryotic target cells. Each of these systems exports distinct DNA or protein substrates to effect a myriad of changes in host cell physiology during infection. Collectively, secretion pathways ancestrally related to bacterial conjugation systems are now referred to as the type IV secretion family. The list of putative type IV family members is increasing rapidly, suggesting that macromolecular transfer by these systems is a widespread phenomenon in nature.

引用

页码：294 / 305

页数：12

共 62 条

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