Sterically demanding, zwitterionic trialkylphosphonium sulfonates as air-stable ligand precursors for efficient palladium-catalyzed cross-couplings of aryl bromides and chlorides

被引：18

作者：

Brown, William S. ^{[1
]}

Boykin, D'Ariel D. ^{[1
]}

Sonnier, M. Quentin, Jr. ^{[1
]}

Clark, William D. ^{[1
]}

Brown, Fallon V. ^{[1
]}

Shaughnessy, Kevin H. ^{[1
]}

机构：

[1] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

来源：

SYNTHESIS-STUTTGART | 2008年 / 12期

关键词：

palladium; cross-coupling; ligands; aqueous-phase catalysis; aryl halides;

D O I：

10.1055/s-2008-1067095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-(Di-tert-butylphosphonium)propane sulfonate (DTB-PPS) and 3-(diadamantylphosphonium)propane sulfonate (DAPPS) are air-stable pre-ligands for aqueous-phase palladium-catalyzed cross-coupling reactions. Both DTBPPS and DAPPS were found to give active catalysts for the Sonogashira coupling of aryl bromides at room temperature and 4-chloroanisole at 80 degrees C. These ligands also gave effective catalysts for the aqueous-phase Suzuki coupling of aryl bromides at room temperature.

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页码：1965 / 1970

页数：6

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