Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke

被引：27

作者：

Riva, Matteo ^{[1
]}

Pappada, Giovanni B. ^{[1
]}

Papadakis, Michalis ^{[2
]}

Cuccione, Elisa ^{[1
]}

Carone, Davide ^{[1
]}

Menendez, Virginia Rodriguez ^{[1
]}

Sganzerla, Erik P. ^{[1
]}

Beretta, Simone ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, I-20900 Monza, MI, Italy

[2] Univ Oxford, Nuffield Dept Clin Med, Acute Stroke Programme, Oxford, England

来源：

EXPERIMENTAL NEUROLOGY | 2012年 / 233卷 / 02期

关键词：

Cerebral hemodynamics; Focal cerebral ischemia; Intracranial collateral flow; Neuroprotection; Acute stroke; BLOOD-FLOW; CIRCULATION; REPERFUSION; VESSELS;

D O I：

10.1016/j.expneurol.2011.12.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was compared to lateral middle cerebral artery territory, during common carotid artery occlusion and middle cerebral artery occlusion in rats. The functional performance of intracranial collaterals, shown by perfusion deficit in the territory of leptomeningeal branches either during common carotid artery occlusion or middle cerebral artery occlusion, showed significant variability among animals and consistently predicted infarct size and functional deficit. Our findings indicate that leptomeningeal collateral flow is a strong predictor of stroke severity in rats, similarly to humans. Monitoring of collateral blood flow in experimental stroke is essential for reducing variability in neuroprotection studies and accelerating the development of collateral therapeutics. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：815 / 820

页数：6

共 19 条

[1] Laser speckle contrast imaging of collateral blood flow during acute ischemic stroke [J].