α-arylation of ketones using highly active, air-stable (DtBPF)PdX2 (X = cl, br) catalysts

被引：104

作者：

Grasa, Gabriela A. ^{[1
]}

Colacot, Thomas J. ^{[1
]}

机构：

[1] Johnson Matthey Catalysis & Chiral Technol, Paulsboro, NJ 08066 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 26期

关键词：

D O I：

10.1021/ol702430a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Arylation of various ketones with aryl chlorides and bromides using the well-defined and air-stable (DtBPF)PdX2 (X = Cl, Br) catalysts gave 80-100% yield of the coupled products under relatively mild conditions at low catalyst loadings. The X-ray structure of (DtBPF)PdCl2 revealed the largest P-Pd-P bite angle (104.2 degrees) for a ferrocenyl bisphosphine ligand. P-31 NMR monitoring of (DtBPF)PdCl2-catalyzed reaction of 4-chlorotoluene with propiophenone indicated that DtBPF remained coordinated in a bidentate mode during the catalytic cycle.

引用

页码：5489 / 5492

页数：4

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