The ubiquitin-proteasome system in Alzheimer's disease

被引：191

作者：

Oddo, Salvatore ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92717 USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2008年 / 12卷 / 02期

关键词：

D O I：

10.1111/j.1582-4934.2008.00276.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system (UPS). Indeed, there is clear genetic and biochemical evidence of an involvement of the ubiquitin proteasome system in AD. This review summarizes the data supporting an involvement of the UPS in the pathogenesis of AD, focusing on the data showing the relationship between A beta and tau, the two hallmark lesions of AD, and the UPS.

引用

页码：363 / 373

页数：11

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