High-dose aspirin is neuroprotective in a rat focal ischemia model

被引:26
作者
Berger, C [1 ]
Xia, F [1 ]
Schabitz, WR [1 ]
Schwab, S [1 ]
Grau, A [1 ]
机构
[1] Heidelberg Univ, Dept Neurol, D-69120 Heidelberg, Germany
关键词
stroke; ischemia; aspirin; neuroprotection;
D O I
10.1016/j.brainres.2003.11.049
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Acetylsalicylic acid (ASA) is neuroprotective through various pharmacological action sites. We used a temporary middle cerebral artery occlusion (tMCAO) model in 56 Wistar rats to assess whether repeated ASA injections at 30 min, 6 h, 1, 2, 3, and 4 days after stroke onset are neuroprotective. Animals were sacrificed 5 days after MCAO; infarct size was analyzed with 2,3,5-triphenyltetrazolium chloride staining. As compared to saline (164+/-13 mm(3), n=14), only repeated injections of 40 mg/kg ASA (79+/-18 mm(3), n=14, P=0.0029), but not of 20 mg/kg ASA (129+/-19 mm(3), n=15), reduced infarct volume significantly. No significant change was noted with 40 mg/kg ASA injected only once at 30 min after MCAO (117+/-16 mm(3), n=13). (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:237 / 242
页数:6
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