PER-7, an Extended-Spectrum β-Lactamase with Increased Activity toward Broad-Spectrum Cephalosporins in Acinetobacter baumannii

被引：55

作者：

Bonnin, Remy A. ^{[1
,2
]}

Potron, Anais ^{[1
,2
]}

Poirel, Laurent ^{[1
,2
]}

Lecuyer, Herve ^{[3
]}

Neri, Rita ^{[1
,2
]}

Nordmann, Patrice ^{[1
,2
]}

机构：

[1] Hop Bicetre, AP HP, Serv Bacteriol Virol, Fac Med,INSERM Emerging Resistance Antibiot U914, F-94275 Le Kremlin Bicetre, France

[2] Univ Paris Sud, F-94275 Le Kremlin Bicetre, France

[3] Hop Necker Enfants Malad, AP HP, Lab Microbiol Hyg Hosp, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 05期

关键词：

PSEUDOMONAS-AERUGINOSA; BIOCHEMICAL-CHARACTERIZATION; CARBAPENEM RESISTANCE; MULTIDRUG-RESISTANCE; GENETIC ENVIRONMENT; EXPRESSION; EMERGENCE; STRAIN; MECHANISMS; VARIANT;

D O I：

10.1128/AAC.01795-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acinetobacter baumannii isolate AP2 was recovered from a bronchial lavage sample of a patient hospitalized in Paris, France. A. baumannii AP2 was resistant to all beta-lactams, including carbapenems, and expressed the extended-spectrum beta-lactamase (ESBL) PER-7, which differs from PER-1 by 4 amino acid substitutions. Compared to PER-1, PER-7 possessed higher-level hydrolytic activities against cephalosporins and aztreonam. The bla(PER-7) gene was chromosomally located and associated with a mosaic class 1 integron structure. Additionally, isolate AP2 expressed the carbapenem-hydrolyzing oxacillinase OXA-23 and the 16S RNA methylase ArmA, conferring high-level resistance to aminoglycosides.

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页码：2424 / 2427

页数：4

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