Flavonoids as cycline-dependent kinase inhibitors: Inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series

被引：30

作者：

Aligiannis, N

Mitaku, S ^{[1
]}

Mitrocotsa, D

Leclerc, S

机构：

[1] Univ Athens, Sch Pharm, Div Pharmacognosy, Dept Pharm, GR-15771 Athens, Greece

[2] CNRS, Biol Stn, Roscoff, France

来源：

PLANTA MEDICA | 2001年 / 67卷 / 05期

关键词：

D O I：

10.1055/s-2001-15807

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In an effort to detect potential inhibitors of cdc25 phosphatase, nineteen flavonoids belonging to the quercetin and kaempferol series have been evaluated, using a colorimetric assay of recombinant human cdc25A tyrosine phosphatase as a cell cycle-specific target. Compounds bearing two benzyl or methyl groups in positions 7 and 4 ' and acetyl on the hydroxy groups of the sugar moiety showed the maximal activity.

引用

页码：468 / 470

页数：3

共 21 条

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