Search for strategies by computer: the CONAN approach. Application to steroid and taxane frameworks

被引：8

作者：

Barone, R ^{[1
]}

Chanon, M ^{[1
]}

机构：

[1] Univ Paul Cezanne, Fac Sci St Jerome, UMR 6178, CNRS,Lab AM3, F-13397 Marseille, France

来源：

TETRAHEDRON | 2005年 / 61卷 / 37期

关键词：

computer-aided organic synthesis; retrosynthesis; strategy; steroid; taxane;

D O I：

10.1016/j.tet.2005.07.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the CONAN (CONnectivity ANalysis) program the aim of which is to search for strategies by simplification of the target skeleton by different types of disconnection. The options available for the disconnections of the target are: add one bond, delete one or two bonds, search for linear precursors, for convergent strategies, for precursors containing a given number of rings and linear chains, and then disconnection of rings by formal [x+y] reaction types like [2 + 2], [4+ 2], etc. Taxane and steroid skeletons have been studied. CONAN runs on PC's microcomputers. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8916 / 8923

页数：8

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