Synthesis of nucleoside analogs and new Tat protein inhibitors

被引：4

作者：

Ané, A

Prestat, G

Manh, GT

Thiam, M

Josse, S

Pipelier, M

Lebreton, J

Pradère, JP

Dubreuil, D

机构：

[1] Fac Sci & Tech, CNRS, UMR 6513, Synth Organ Lab, F-44322 Nantes 3, France

[2] Fac Sci & Tech, Chim Organ Struct Lab, Abidjan, Cote Ivoire

[3] Univ Cheikh Anta Diop, Fac Sci & Tech, Synth Organ Lab, Dakar, Senegal

来源：

PURE AND APPLIED CHEMISTRY | 2001年 / 73卷 / 07期

关键词：

D O I：

10.1351/pac200173071189

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N- and C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic research programs carried out in collaboration with the laboratory of Nantes.

引用

收藏

页码：1189 / 1196

页数：8

相关论文

共 49 条

[1] ELECTROCHEMICAL REDUCTION OF 4H-1,3-THIAZINES - SYNTHESIS OF SUBSTITUTED PYRROLES AND (OR) 6H-1,3-THIAZINES [J].

ABOUELFIDA, A ;

PRADERE, JP ;

JUBAULT, M ;

TALLEC, A .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1992, 70 (01) :14-20

[2] 1,2,3-TRIAZOLE-[2',5'-BIS-O-(TERT-BUTYLDIMETHYLSILYL)-BETA-D-RIBOFURANOSYL]-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOL 2'',2''-DIOXIDE) (TSAO) ANALOGS - SYNTHESIS AND ANTI-HIV-1 ACTIVITY [J].

ALVAREZ, R ;

VELAZQUEZ, S ;

SANFELIX, A ;

AQUARO, S ;

DECLERCQ, E ;

PERNO, CF ;

KARLSSON, A ;

BALZARINI, J ;

CAMARASA, MJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (24) :4185-4194

[3]

BALZARINI J, 1988, MOL PHARMACOL, V33, P243

[4] THERMAL CYCLOADDITION OF DIMETHYL "1,2,4,5-TETRAZINE-3,6-DICARBOXYLATE WITH ELECTRON-RICH OLEFINS - 1,2-DIAZINE AND PYRROLE INTRODUCTION - PREPARATION OF OCTAMETHYLPORPHIN (OMP) [J].

BOGER, DL ;

COLEMAN, RS ;

PANEK, JS ;

YOHANNES, D .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (23) :4405-4409

[5] Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels-Alder reactions [J].

Boger, DL ;

Boyce, CW ;

Labroli, MA ;

Sehon, CA ;

Jin, Q .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (01) :54-62

[6]

BOGER DL, 1908, HETERO DIELS ALDER M

[7] SUBSTITUTED 1-THIA-3-AZA-1,3-BUTADIENE - DIELS-ALDER REACTION WITH METHYLACRYLATE - DETERMINATION OF ACTIVATION PARAMETERS [J].

CHEHNA, M ;

PRADERE, JP ;

QUINIOU, H ;

LEBOTLAN, D ;

TOUPET, L .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1989, 42 (1-2) :15-19

[8] Uracil- and thymine-substituted thymidine and uridine derivatives [J].

Costa, AM ;

Faja, M ;

Farràs, J ;

Vilarrasa, J .

TETRAHEDRON LETTERS, 1998, 39 (13) :1835-1838

[9] ADDITION OF ORGANOMETALLICS ON ALPHA,BETA-UNSATURATED THIOCARBONYL COMPOUNDS .2. MICHAEL ADDITION OF LITHIUM ENOLATES ON THIOAMIDE AND DITHIOCARBAMATE VINYLOGS AND THIOAROYLFORMAMIDINE [J].

GUEMAS, J ;

LEES, M ;

RELIQUET, A ;

VILLIERAS, J .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1982, 12 (03) :325-339

[10] AIDS-DRIVEN NUCLEOSIDE CHEMISTRY [J].

HURYN, DM ;

OKABE, M .

CHEMICAL REVIEWS, 1992, 92 (08) :1745-1768

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