Synthesis of nucleoside analogs and new Tat protein inhibitors

被引：4

作者：

Ané, A

Prestat, G

Manh, GT

Thiam, M

Josse, S

Pipelier, M

Lebreton, J

Pradère, JP

Dubreuil, D

机构：

[1] Fac Sci & Tech, CNRS, UMR 6513, Synth Organ Lab, F-44322 Nantes 3, France

[2] Fac Sci & Tech, Chim Organ Struct Lab, Abidjan, Cote Ivoire

[3] Univ Cheikh Anta Diop, Fac Sci & Tech, Synth Organ Lab, Dakar, Senegal

来源：

PURE AND APPLIED CHEMISTRY | 2001年 / 73卷 / 07期

关键词：

D O I：

10.1351/pac200173071189

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N- and C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic research programs carried out in collaboration with the laboratory of Nantes.

引用

收藏

页码：1189 / 1196

页数：8

相关论文

共 49 条

[21]

MESLIN JC, 1979, B SOC CHIM FR II-CH, P347

[22] HETEROATOMIC LINKAGES AND THEIR CYCLIZATION PRODUCTS .2. SUBSTITUTED N'-THIOAROYL-N,N-DIMETHYLFORMAMIDINES, 5-AROYLTHIAZOLES AND 6H-1,3-THIAZIN-6-ONES(THIONES) [J].

MESLIN, JC ;

QUINIOU, H .

TETRAHEDRON, 1975, 31 (24) :3055-3058

[23] STRATEGIES FOR ANTIVIRAL THERAPY IN AIDS [J].

MITSUYA, H ;

BRODER, S .

NATURE, 1987, 325 (6107) :773-778

[24] ISODIDEOXYNUCLEOSIDES - A CONCEPTUALLY NEW CLASS OF NUCLEOSIDE ANTIVIRAL AGENTS [J].

NAIR, V ;

NUESCA, ZM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (20) :7951-7953

[25] INHIBITION OF REVERSE-TRANSCRIPTASE ACTIVITY BY 2',3'-DIDEOXYTHYMIDINE 5'-TRIPHOSPHATE AND ITS DERIVATIVES MODIFIED ON THE 3' POSITION [J].

ONO, K ;

OGASAWARA, M ;

IWATA, Y ;

NAKANE, H ;

FUJII, T ;

SAWAI, K ;

SANEYOSHI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 140 (02) :498-507

[26] SYNTHESIS OF (1-[2',5'-BIS-O-(T-BUTYLDIMETHYLSILYL)-BETA-D-XYLO AND BETA-D-RIBOFURANOSYL]THYMINE)-3'-SPIRO-5''-(4''-AMINO-1'',2''-OXATHIOLE-2'',2''-DIOXIDE) (TSAO) - A NOVEL TYPE OF SPECIFIC ANTI-HIV AGENTS [J].

PEREZPEREZ, MJ ;

SANFELIX, A ;

CAMARASA, MJ ;

BALZARINI, J ;

DECLERCQ, E .

TETRAHEDRON LETTERS, 1992, 33 (21) :3029-3032

[27] NUCLEOSIDE ANALOGS AS CHEMOTHERAPEUTIC-AGENTS - A REVIEW [J].

PERIGAUD, C ;

GOSSELIN, G ;

IMBACH, JL .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1992, 11 (2-4) :903-945

[28]

PRADERE JP, 1993, B SOC CHIM FR, V130, P610

[29] 6H-1,3-THIAZINES IN CEPHEMES USING CYCLOCONDENSATION [J].

PRADERE, JP ;

ROZE, JC ;

QUINIOU, H ;

DANIONBOUGOT, R ;

DANION, D ;

TOUPET, L .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1986, 64 (03) :597-602

[30] Synthesis of 3′-O2-(azaheterocycle)-thymidines [J].

Prestat, G ;

Dubreuil, D ;

Adjou, A ;

Pradère, JP ;

Lebreton, J ;

Evers, M ;

Henin, Y .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2000, 19 (04) :735-748

← 1 2 3 4 5 →