The dark side of dioxygen biochemistry

被引：181

作者：

Valentine, JS ^{[1
]}

Wertz, DL ^{[1
]}

Lyons, TJ ^{[1
]}

Liou, LL ^{[1
]}

Goto, JJ ^{[1
]}

Gralla, EB ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(98)80067-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular biochemistry of dioxygen is Janus-faced. The good side includes numerous enzyme-catalyzed reactions of dioxygen that occur in respiration and normal metabolism, while the dark side encompasses deleterious reactions of species derived from dioxygen that lead to damage of cellular components. These reactive oxygen species have historically been perceived almost exclusively as agents of the dark side, but it has recently become clear that they play beneficial roles as well.

引用

页码：253 / 262

页数：10

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