The dark side of dioxygen biochemistry

被引：181

作者：

Valentine, JS ^{[1
]}

Wertz, DL ^{[1
]}

Lyons, TJ ^{[1
]}

Liou, LL ^{[1
]}

Goto, JJ ^{[1
]}

Gralla, EB ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(98)80067-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular biochemistry of dioxygen is Janus-faced. The good side includes numerous enzyme-catalyzed reactions of dioxygen that occur in respiration and normal metabolism, while the dark side encompasses deleterious reactions of species derived from dioxygen that lead to damage of cellular components. These reactive oxygen species have historically been perceived almost exclusively as agents of the dark side, but it has recently become clear that they play beneficial roles as well.

引用

页码：253 / 262

页数：10

共 86 条

[31] Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes: Detection of 4-hydroxynonenal- and malondialdehyde-protein adducts [J].

Hartley, DP ;

Kroll, DJ ;

Petersen, DR .

CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (08) :895-905

[32] Formation, prevention, and repair of DNA damage by iron hydrogen peroxide [J].

Henle, ES ;

Linn, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19095-19098

[33] Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator [J].

Hidalgo, E ;

Ding, HG ;

Demple, B .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (06) :207-210

[34] Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia [J].

Ho, YS ;

Magnenat, JL ;

Bronson, RT ;

Cao, J ;

Gargano, M ;

Sugawara, M ;

Funk, CD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) :16644-16651

[35]

Hosler BA, 1996, CURR OPIN NEUROL, V9, P486

[36] Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts [J].

Huang, TT ;

Yasunami, M ;

Carlson, EJ ;

Gillespie, AM ;

Reaume, AG ;

Hoffman, EK ;

Chan, PH ;

Scott, RW ;

Epstein, CJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 344 (02) :424-432

[37] Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts [J].

Irani, K ;

Xia, Y ;

Zweier, JL ;

Sollott, SJ ;

Der, CJ ;

Fearon, ER ;

Sundaresan, M ;

Finkel, T ;

GoldschmidtClermont, PJ .

SCIENCE, 1997, 275 (5306) :1649-1652

[38]

KEYER K, 1996, P NATL ACAD SCI USA, V93, P18635

[39] Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O-2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity [J].

Khoroshilova, N ;

Popescu, C ;

Munck, E ;

Beinert, H ;

Kiley, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6087-6092

[40] Differential expression of superoxide dismutases containing Ni and Fe/Zn in Streptomyces coelicolor [J].

Kim, EJ ;

Kim, HP ;

Hah, YC ;

Roe, JH .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 241 (01) :178-185

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