In vivo evaluation of the NEDO biventricular assist device with an RPM dynamic impeller suspension system

被引：6

作者：

Ichikawa, S

Linneweber, J

Motomura, T

Ishitoya, H

Watanabe, K

Ashizawa, S

Murai, N

Nishimura, I

Sumikura, H

Glueck, JA

Shinohara, T

Oestmann, DJ

Nosé, Y

机构：

[1] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA

[2] Miwatec Co Ltd, Tokyo, Japan

来源：

ASAIO JOURNAL | 2003年 / 49卷 / 05期

关键词：

D O I：

10.1097/01.MAT.0000084104.91081.7B

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Since 1995, the Baylor College of Medicine group has been developing the NEDO Gyro permanent implantable (PI) pump. The Gyro PI pump has achieved outstanding results up to 284 days with no thrombus formation during the left ventricular assist device (LVAD) animal experiments. However, in biventricular assist device (BVAD) animal experiments, thrombus formation did occur. An in vitro experiment showed the reason for thrombus formation was caused by the missed magnetic balance between the impeller and the actuator. On the basis of this result, the revolutions per minute (RPM) impeller suspension system was developed. Six long-term animal studies were performed in bovine models. Survival periods were 90, 80, 60, 51, 48, and 37 days, respectively. No thrombus was observed in the pumps with the exception of one right pump. In that experiment, the thrombus formation may have occurred when the pump had a low flow because of outflow kinking. In this article, the anti-thrombogenic effect of this RPM impeller suspension system will be discussed.

引用

页码：578 / 582

页数：5

共 12 条

[1]

The balance of the impeller-driver magnet affects the antithrombogenicity in the gyro permanently implantable pump [J].

Ichikawa, S ;

Nishimura, I ;

Mikami, M ;

Nonaka, K ;

Linneweber, J ;

Kawahito, S ;

Motomura, T ;

Ishitoya, H ;

Glueck, J ;

Shinohara, T ;

Nosé, Y .

ARTIFICIAL ORGANS, 2002, 26 (11) :927-930

[2]

The HeartMate III: Design and in vivo studies of a Maglev centrifugal left ventricular assist device [J].

Loree, HM ;

Bourque, K ;

Gernes, DB ;

Richardson, JS ;

Poirier, VL ;

Barletta, N ;

Fleischli, A ;

Foiera, G ;

Gempp, TM ;

Schoeb, R ;

Litwak, KN ;

Akimoto, T ;

Kameneva, M ;

Watach, MJ ;

Litwak, P .

ARTIFICIAL ORGANS, 2001, 25 (05) :386-391

[3]

Evaluation of the wear of the pivot bearing in the Gyro C1E3 pump [J].

Makinouchi, K ;

Nakazawa, T ;

Takami, Y ;

Takatani, S ;

Nose, Y .

ARTIFICIAL ORGANS, 1996, 20 (06) :523-528

[4]

Physiological adaptation to a nonpulsatile biventricular assist system [J].

Murai, N ;

Ichikawa, S ;

Watanabe, K ;

Shinohara, T ;

Glueck, J ;

Motomura, T ;

Ishitoya, H ;

Ashizawa, S ;

Matsui, T ;

Sumikura, H ;

Ichihashi, F ;

Nosé, Y .

ASAIO JOURNAL, 2003, 49 (03) :345-348

[5]

Development status of terumo implantable left ventricular assist system [J].

Nojiri, C ;

Kijima, T ;

Maekawa, J ;

Horiuchi, K ;

Kido, T ;

Sugiyama, T ;

Mori, T ;

Sugiura, N ;

Asada, T ;

Umemura, W ;

Ozaki, T ;

Suzuki, M ;

Akamatsu, T ;

Westaby, S ;

Katsumata, T ;

Saito, S .

ARTIFICIAL ORGANS, 2001, 25 (05) :411-413

[6]

Development of the Baylor Gyro permanently implantable centrifugal blood pump as a biventricular assist device [J].

Nonaka, K ;

Linneweber, J ;

Ichikawa, S ;

Yoshikawa, T ;

Kawahito, S ;

Mikami, M ;

Motomura, T ;

Ishitoya, H ;

Nishimura, I ;

Oestmann, D ;

Glueck, J ;

Schima, H ;

Wolner, E ;

Shinohara, T ;

Nosé, Y .

ARTIFICIAL ORGANS, 2001, 25 (09) :675-682

[7]

Clinical experience with the MicroMed DeBakey ventricular assist device [J].

Noon, GP ;

Morley, DL ;

Irwin, S ;

Abdelsayed, SV ;

Benkowski, RJ ;

Lynch, BE .

ANNALS OF THORACIC SURGERY, 2001, 71 (03) :S133-S138

[8]

NOSE Y, 1993, ARTIF ORGANS, V17, P92

[9]

Development of rotary blood pump technology:: Past, present, and future [J].

Nosé, Y ;

Yoshikawa, M ;

Murabayashi, S ;

Takano, T .

ARTIFICIAL ORGANS, 2000, 24 (06) :412-420

[10]

Long-term in vivo left ventricular assist device study for 284 days with Gyro PI pump [J].

Ohtsuka, G ;

Nakata, K ;

Yoshikawa, M ;

Takano, T ;

Glueck, J ;

Sankai, Y ;

Takami, Y ;

Mueller, J ;

Sueoka, A ;

Letsou, G ;

Schima, H ;

Schmallegger, H ;

Wolner, E ;

Koyanagi, H ;

Fujisawa, A ;

Baldwin, JC ;

Nosé, Y .

ARTIFICIAL ORGANS, 1999, 23 (06) :504-507

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