HPLC-MS analysis and anti-oedematogenic activity of Hypericum grandifolium choisy (Hypericaceae)

被引：14

作者：

Bonkanka, Celia X. ^{[1
]}

Smelcerovic, Andrija ^{[2
]}

Zuehlke, Sebastian ^{[2
]}

Rabanal, Rosa Maria ^{[1
]}

Spiteller, Michael ^{[2
]}

Sanchez-Mateo, Candelaria del Carmen ^{[1
]}

机构：

[1] Univ La Laguna, Fac Pharm, Dept Pharmacol, Tenerife 38071, Spain

[2] Univ Dortmund, Inst Environm Res, Dortmund, Germany

来源：

PLANTA MEDICA | 2008年 / 74卷 / 07期

关键词：

Hypericum grondifolium choisy; Hypericaceae; phenolic compounds; HPLC-MS/MS; HPLC-FT/MS; in vivo anti-oedematogenic activity;

D O I：

10.1055/s-2008-1074526

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A study has been carried out on the chemical composition and in vivo anti-oedematogenic activity of several extracts from Hypericum grandifolium Choisy (Hypericaceae) collected in Tenerife (Canary Islands). The HPLC-MS analysis (HPLC-ESI/MS and HPLC-FT/MS) revealed the presence of hyperforin, flavonoids and probably benzophenone derivatives, while naphthodianthrones were absent. Pharmacological results revealed that the methanol extracts and the aqueous, butanol and chloroform fractions obtained therefrom possess anti-oedematogenic activity against TPA-induced ear oedema and carrageenan-induced paw oedema, the chloroform fraction being the most active. Subfractions derived from the chloroform fraction also showed anti-oedematogenic activity. From these results, it can be suggested that different constituents, such as the flavonoids and the benzophenone derivatives, could be responsible, at least in part, for the anti-oedematogenic effects observed for this species.

引用

页码：719 / 725

页数：7

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