Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules

被引:38
作者
Calixto, JB
Campos, MM
Otuki, MF
Santos, ARS
机构
[1] Univ Fed Santa Catarina, Dept Pharmacol, CCB, BR-88015420 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Physiol Sci, CCB, BR-88015420 Florianopolis, SC, Brazil
关键词
medicinal plants; plant constituents; inflammation; cytokines; chemokines; adhesion molecules;
D O I
10.1055/s-2004-815483
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
It has been widely shown that many plant-derived compounds present significant anti-inflammatory effects. For this reason, they represent potential molecules for the development of new drugs, especially designed for the treatment and/or control of chronic inflammatory states such as rheumatism, asthma, inflammatory bowel diseases, atherosclerosis, etc. This review focuses on the naturally-occurring compounds with anti-inflammatory properties and attempts to correlate their actions with the modulation of cytokines and associated intracellular signalling pathways; it continues the review published in the November, 2003 issue of Planta Medica.
引用
收藏
页码:93 / 103
页数:11
相关论文
共 106 条
[1]  
Aggarwal BB, 2003, ANTICANCER RES, V23, P363
[2]   Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells [J].
Ahn, KS ;
Kim, JH ;
Oh, SR ;
Ryu, SY ;
Lee, HK .
PLANTA MEDICA, 2000, 66 (07) :641-644
[3]   Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules [J].
Ahn, KS ;
Jung, KY ;
Kim, JH ;
Oh, SR ;
Lee, HK .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2001, 24 (09) :1085-1087
[4]   Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease [J].
Allison, AC ;
Cacabelos, R ;
Lombardi, VRM ;
Alvarez, XA ;
Vigo, C .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (07) :1341-1357
[5]   Inhibition of TNF-α, IL-1β, and IL-6 productions and NF-κB activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated ftom Catalpa ovata G. Don (Bignoniaceae) [J].
An, SJ ;
Pae, HO ;
Oh, GS ;
Choi, BM ;
Jeong, S ;
Jang, SI ;
Oh, H ;
Kwon, TO ;
Song, CE ;
Chung, HT .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (08) :1173-1181
[6]   Cytokines and anti-cytokine biologicals in autoimmunity: present and future [J].
Andreakos, ET ;
Foxwell, BM ;
Brennan, FM ;
Maini, RN ;
Feldmann, M .
CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (4-5) :299-313
[7]   Colchicine and griseofulvin inhibit VCAM-1 expression on human vascular endothelial cells - evidence for the association of VCAM-1 expression with microtubules [J].
Asahina, A ;
Tada, Y ;
Nakamura, K ;
Tamaki, K .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2001, 25 (01) :1-9
[8]   Piceatannol inhibits TNF-induced NF-κB activation and NF-κB-mediated gene expression through suppression of IκBα kinase and p65 phosphorylation [J].
Ashikawa, K ;
Majumdar, S ;
Banerjee, S ;
Bharti, AC ;
Shishodia, S ;
Aggarwal, BB .
JOURNAL OF IMMUNOLOGY, 2002, 169 (11) :6490-6497
[9]   Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat [J].
Banerjee, M ;
Tripathi, LM ;
Srivastava, VML ;
Puri, A ;
Shukla, R .
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2003, 25 (02) :213-224
[10]   Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].
Barnes, PJ ;
Larin, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071