Heterogeneous Catalytic Hydrogenation Reactions in Continuous-Flow Reactors

被引：317

作者：

Irfan, Muhammad ^{[1
,2
]}

Glasnov, Toma N. ^{[1
,2
]}

Kappe, C. Oliver ^{[1
,2
]}

机构：

[1] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

[2] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

CHEMSUSCHEM | 2011年 / 4卷 / 03期

关键词：

flow chemistry; heterogeneous catalysis; hydrogenation; microreactors; process intensification; CONTINUOUS ENANTIOSELECTIVE HYDROGENATION; FIXED-BED REACTOR; SUPERCRITICAL CARBON-DIOXIDE; ENANTIO-SELECTIVE HYDROGENATION; TRANSITION-METAL-COMPLEXES; LIQUID-PHASE HYDROGENATION; PROTECTING GROUP REMOVAL; ETHYL PYRUVATE; HIGH-PRESSURE; ASYMMETRIC HYDROGENATION;

D O I：

10.1002/cssc.201000354

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microreactor technology and continuous flow processing in general are key features in making organic synthesis both more economical and environmentally friendly. Heterogeneous catalytic hydrogenation reactions under continuous flow conditions offer significant benefits compared to batch processes which are related to the unique gas-liquid-solid triphasic reaction conditions present in these transformations. In this review article recent developments in continuous flow heterogeneous catalytic hydrogenation reactions using molecular hydrogen are summarized. Available flow hydrogenation techniques, reactors, commonly used catalysts and examples of synthetic applications with an emphasis on laboratory-scale flow hydrogenation reactions are presented.

引用

页码：300 / 316

页数：17

共 227 条

[1] Micro-structured reactors as a tool for chiral modifier screening in gas-liquid-solid asymmetric hydrogenations [J].