Prenylated xanthones from Garcinia xanthochymus

被引：27

作者：

Chanmahasathien, W

Li, YS

Satake, M

Oshima, Y

Ishibashi, M

Ruangrungsi, N

Ohizumi, Y ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, Grad Sch Life Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

[3] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[4] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 11期

关键词：

Garcinia xanthochymus; Guttiferae; xanthone; nerve growth factor (NGF)-potentiating activity; PC12D cell;

D O I：

10.1248/cpb.51.1332

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 mum) and 2 (10 mum) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.

引用

页码：1332 / 1334

页数：3

共 12 条

[1] Cytotoxic xanthones from Garcinia hanburyi [J].