Xanthones with antimalarial activity from Garcinia dulcis

被引：57

作者：

Likhitwitayawuid, K ^{[1
]}

Chanmahasathien, W

Ruangrungsi, N

Krungkrai, J

机构：

[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok 10330, Thailand

来源：

PLANTA MEDICA | 1998年 / 64卷 / 03期

关键词：

D O I：

10.1055/s-2006-957429

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 mu g/ml. In addition, revised C-13-NMR assignments of 3 and complete C-13-NMR assignments of 4 were obtained through analysis of their COSY, NOESY HMQC, and HMBC spectra.

引用

页码：281 / 282

页数：2

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