Interactions between bacterial pathogens and mitochondrial cell death pathways

被引：123

作者：

Rudel, Thomas ^{[1
]}

Kepp, Oliver ^{[2
]}

Kozjak-Pavlovic, Vera ^{[1
]}

机构：

[1] Univ Wurzburg, Lehrstuhl Mikrobiol, D-97074 Wurzburg, Germany

[2] INSERM U848, Inst Gustav Roussy, Fac Sud Univ Paris, F-94804 Villejuif, France

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 10期

关键词：

ENTEROPATHOGENIC ESCHERICHIA-COLI; TUMOR-NECROSIS-FACTOR; TRACHOMATIS-INFECTED CELLS; CYTOCHROME-C RELEASE; HELICOBACTER-PYLORI; VACUOLATING CYTOTOXIN; EPITHELIAL-CELLS; BH3-ONLY PROTEINS; ALPHA-TOXIN; CHLAMYDOPHILA-PNEUMONIAE;

D O I：

10.1038/nrmicro2421

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The modulation of host cell death pathways by bacteria has been recognized as a major pathogenicity mechanism. Among other strategies, bacterial pathogens can hijack the cell death machinery of host cells by influencing the signalling pathways that converge on the mitochondria. In particular, many bacterial proteins have evolved to interact in a highly specific manner with host mitochondria, thereby modulating the decision between cell life and death. In this Review, we explore the intimate interactions between bacterial pathogens and mitochondrial cell death pathways.

引用

页码：693 / 705

页数：13

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