Interactions between bacterial pathogens and mitochondrial cell death pathways

被引：123

作者：

Rudel, Thomas ^{[1
]}

Kepp, Oliver ^{[2
]}

Kozjak-Pavlovic, Vera ^{[1
]}

机构：

[1] Univ Wurzburg, Lehrstuhl Mikrobiol, D-97074 Wurzburg, Germany

[2] INSERM U848, Inst Gustav Roussy, Fac Sud Univ Paris, F-94804 Villejuif, France

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 10期

关键词：

ENTEROPATHOGENIC ESCHERICHIA-COLI; TUMOR-NECROSIS-FACTOR; TRACHOMATIS-INFECTED CELLS; CYTOCHROME-C RELEASE; HELICOBACTER-PYLORI; VACUOLATING CYTOTOXIN; EPITHELIAL-CELLS; BH3-ONLY PROTEINS; ALPHA-TOXIN; CHLAMYDOPHILA-PNEUMONIAE;

D O I：

10.1038/nrmicro2421

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The modulation of host cell death pathways by bacteria has been recognized as a major pathogenicity mechanism. Among other strategies, bacterial pathogens can hijack the cell death machinery of host cells by influencing the signalling pathways that converge on the mitochondria. In particular, many bacterial proteins have evolved to interact in a highly specific manner with host mitochondria, thereby modulating the decision between cell life and death. In this Review, we explore the intimate interactions between bacterial pathogens and mitochondrial cell death pathways.

引用

页码：693 / 705

页数：13

共 111 条

[61] Bacterial proteins predisposed for targeting to mitochondria [J].

Lucattini, R ;

Likic, VA ;

Lithgow, T .

MOLECULAR BIOLOGY AND EVOLUTION, 2004, 21 (04) :652-658

[62] Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo:: role of mitochondrial associated protein (Map) [J].

Ma, Caixia ;

Wickham, Mark E. ;

Guttman, Julian A. ;

Deng, Wanyin ;

Walker, John ;

Madsen, Karen L. ;

Jacobson, Kevan ;

Vogl, Wayne A. ;

Finlay, B. Brett ;

Vallance, Bruce A. .

CELLULAR MICROBIOLOGY, 2006, 8 (10) :1669-1686

[63]

MAJNO G, 1995, AM J PATHOL, V146, P3

[64] Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis [J].

Massari, P ;

Ho, Y ;

Wetzler, LM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9070-9075

[65] Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria -: Involvement of ATP-sensitive mitochondrial potassium channels [J].

Matarrese, Paola ;

Falzano, Loredana ;

Fabbri, Alessia ;

Gambardella, Lucrezia ;

Frank, Claudio ;

Geny, Blandine ;

Popoff, Michel R. ;

Malorni, Walter ;

Fiorentini, Carla .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (12) :9029-9041

[66] Necrotic death pathway in Fas receptor signaling [J].

Matsumura, H ;

Shimizu, Y ;

Ohsawa, Y ;

Kawahara, A ;

Uchiyama, Y ;

Nagata, S .

JOURNAL OF CELL BIOLOGY, 2000, 151 (06) :1247-1255

[67] Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells [J].

Müller, A ;

Günther, D ;

Brinkmann, V ;

Hurwitz, R ;

Meyer, TF ;

Rudel, T .

EMBO JOURNAL, 2000, 19 (20) :5332-5343

[68] Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis -: Critical role of the 16th leucine residue in EspF [J].

Nagai, T ;

Abe, A ;

Sasakawa, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (04) :2998-3011

[69] Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin [J].

Nguyen, VQ ;

Caprioli, RM ;

Cover, TL .

INFECTION AND IMMUNITY, 2001, 69 (01) :543-546

[70] Anaplasma phagocytophilum Ats-1 Is Imported into Host Cell Mitochondria and Interferes with Apoptosis Induction [J].

Niu, Hua ;

Kozjak-Pavlovic, Vera ;

Rudel, Thomas ;

Rikihisa, Yasuko .

PLOS PATHOGENS, 2010, 6 (02)

← 2 3 4 5 6 7 8 9 10 11 →