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Living on a break: cellular senescence as a DNA-damage response

被引：808
作者：
di Fagagna, Fabrizio d'Adda [1 ]
机构：
[1] IFOM Fdn, FIRC Inst Mol Oncol Fdn, I-20139 Milan, Italy
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 07期
关键词：
D O I：
10.1038/nrc2440
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.
引用
收藏
页码：512 / 522
页数：11
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