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Living on a break: cellular senescence as a DNA-damage response

被引：808
作者：
di Fagagna, Fabrizio d'Adda [1 ]
机构：
[1] IFOM Fdn, FIRC Inst Mol Oncol Fdn, I-20139 Milan, Italy
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 07期
关键词：
D O I：
10.1038/nrc2440
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-suppressive function. Common to both ageing and cancer is the generation of DNA damage and the engagement of the DNA-damage response pathways. In this Review, the diverse mechanisms that lead to DNA-damage generation and the activation of DNA-damage-response signalling pathways are discussed, together with the evidence for their contribution to the establishment and maintenance of cellular senescence in the context of organismal ageing and cancer development.
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页码：512 / 522
页数：11
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