A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks

被引：22

作者：

Albericio, F

Burger, K

Ruíz-Rodríguez, J

Spengler, J

机构：

[1] Univ Barcelona, Barcelona Biomed Res Inst, E-08028 Barcelona, Spain

[2] Univ Leipzig, Dept Organ Chem, D-04103 Leipzig, Germany

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1021/ol047653v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The technique of choice for synthesis of small-scale depsipeptides is on a solid support. However, if expensive monomers have to be incorporated, solid-phase synthesis can quickly turn out to be unattractive because of its low atom economy. Herein, we describe a new type of recoverable and reuseable alpha-hydroxy acid building block for solid-phase synthesis and its application in the synthesis of a number of small cyclic depsipeptides.

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页码：597 / 600

页数：4

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