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The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

被引：107
作者：
Crusio, K. M. [1 ,2 ,3 ]
King, B. [1 ,2 ,3 ]
Reavie, L. B. [1 ,2 ,3 ]
Aifantis, I. [1 ,2 ,3 ]
机构：
[1] NYU, Sch Med, Howard Hughes Med Inst, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, NYU Canc Inst, New York, NY 10016 USA
[3] NYU, Sch Med, Helen & Martin S Kimmel Stem Cell Ctr, New York, NY 10016 USA
来源：
ONCOGENE | 2010年 / 29卷 / 35期
基金：
美国国家卫生研究院;
关键词：
Fbw7; ubiquitin-proteasome system; GSK-3; beta; p53; F-BOX PROTEIN; PHOSPHORYLATION-DEPENDENT DEGRADATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; DNA-DAMAGE-RESPONSE; CELL SELF-RENEWAL; C-MYC PROTEIN; TUMOR-SUPPRESSOR; CYCLIN-E; CHROMOSOMAL INSTABILITY; FBXW7; ACTS;
D O I：
10.1038/onc.2010.222
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptional activation. Given its role as a regulator of cellular homeostasis it is not surprising that members of the UPS are frequently aberrantly expressed in a number of disease states including cancer. This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) and mechanisms by which Fbw7 interacts with its substrates in the context of development and tumorigenesis will be discussed. In addition, antagonists of this pathway as well as current and future therapeutics for the UPS will be examined. Oncogene (2010) 29, 4865-4873; doi: 10.1038/onc.2010.222; published online 14 June 2010
引用
收藏
页码：4865 / 4873
页数：9
相关论文
共 80 条
[41]   The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian sel-10 homolog [J].
Öberg, C ;
Li, JH ;
Pauley, A ;
Wolf, E ;
Gurney, M ;
Lendahl, U .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35847-35853
[42]   The myb gene family in cell growth, differentiation and apoptosis [J].
Oh, IH ;
Reddy, EP .
ONCOGENE, 1999, 18 (19) :3017-3033
[43]   Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis [J].
Onoyama, Ichiro ;
Tsunematsu, Ryosuke ;
Matsumoto, Akinobu ;
Kimura, Taichi ;
de Alboran, Ignacio Moreno ;
Nakayama, Keiko ;
Nakayama, Keiichi I. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) :2875-2888
[44]   Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia [J].
Palomero, Teresa ;
T Odom, Duncan ;
O'Neil, Jennifer ;
Ferrando, Adolfo A. ;
Margolin, Adam ;
Neuberg, Donna S. ;
Winter, Stuart S. ;
Larson, Richard S. ;
Li, Wei ;
Liu, X. Shirley ;
Young, Richard A. ;
Look, A. Thomas .
BLOOD, 2006, 108 (03) :986-992
[45]   The ubiquitin system, disease, and drug discovery [J].
Petroski, Matthew D. .
BMC BIOCHEMISTRY, 2008, 9
[46]   Ubiquitin: structures, functions, mechanisms [J].
Pickart, CM ;
Eddins, MJ .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1695 (1-3) :55-72
[47]   Fbw7 and Usp28 regulate Myc protein stability in response to DNA damage [J].
Popov, Nikita ;
Herold, Steffi ;
Llamazares, Maria ;
Schuelein, Christina ;
Eilers, Martin .
CELL CYCLE, 2007, 6 (19) :2327-2331
[48]   The ubiquitin-specific protease USP28 is required for MYC stability [J].
Popov, Nikita ;
Wanzel, Michael ;
Madiredjo, Mandy ;
Zhang, Dong ;
Beijersbergen, Roderick ;
Bernards, Rene ;
Moll, Roland ;
Elledge, Stephen J. ;
Eilers, Martin .
NATURE CELL BIOLOGY, 2007, 9 (07) :765-U71
[49]   Notch1 expression in early lymphopoiesis influences B versus T lineage determination [J].
Pui, JC ;
Allman, D ;
Xu, LW ;
DeRocco, S ;
Karnell, FG ;
Bakkour, S ;
Lee, JY ;
Kadesch, T ;
Hardy, RR ;
Aster, JC ;
Pear, WS .
IMMUNITY, 1999, 11 (03) :299-308
[50]   Inactivation of hCDC4 can cause chromosomal instability [J].
Rajagopalan, H ;
Jallepalli, PV ;
Rago, C ;
Velculescu, VE ;
Kinzler, KW ;
Vogelstein, B ;
Lengauer, C .
NATURE, 2004, 428 (6978) :77-81
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