Comprehensive proteomics

被引：72

作者：

Beck, Martin ^{[2
]}

Claassen, Manfred ^{[1
,3
,4
]}

Aebersold, Ruedi ^{[1
,4
,5
]}

机构：

[1] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland

[2] European Mol Biol Lab, D-69117 Heidelberg, Germany

[3] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Comp Sci, CH-8092 Zurich, Switzerland

[4] Ctr Syst Physiol & Metab Dis, Zurich, Switzerland

[5] Univ Zurich, Fac Sci, CH-8006 Zurich, Switzerland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2011年 / 22卷 / 01期

关键词：

COVERAGE PREDICTION; GLOBAL ANALYSIS; PROTEIN; IDENTIFICATIONS; EXPRESSION;

D O I：

10.1016/j.copbio.2010.09.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Extensive proteome discovery projects using a variety of mass spectrometric techniques have identified proteins matching to 50-70% of the predicted gene models of various species. Comprehensive proteome coverage is desirable for the unbiased comparison of protein quantities between different biological states and for the meaningful comparison of data from multiple samples. Here we discuss the feasibility of this goal in the light of recent technological developments.

引用

页码：3 / 8

页数：6

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