Nanofibers and lyotropic liquid crystals from a class of self-assembling β-peptides

被引：82

作者：

Pomerantz, William C. ^{[2
]}

Yuwono, Virany M. ^{[1
]}

Pizzey, Claire L. ^{[3
]}

Hartgerink, Jeffery D. ^{[1
]}

Abbott, Nicholas L. ^{[3
]}

Gellman, Samuel H. ^{[2
]}

机构：

[1] Rice Univ, Dept Chem & Bioengn, Houston, TX 77005 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期

关键词：

liquid crystals; lyotropic phases; nanofibers; peptides; self-assembly;

D O I：

10.1002/anie.200704372

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) More than a pretty phase: A class of helical b-peptides has been discovered that form lyotropicliquid-c rystalline (LC) phases in water. The β-peptide sequence strongly affects the mode of assembly and ultimately whether a LC phase is formed. For a non-globally amphiphilic β-peptide that can form a LC phase, cryo-TEM revealed thin fibers several micrometers in length, consistent with Onsager theory. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1241 / 1244

页数：4

共 28 条

[1] Hierarchical self-assembly of chiral rod-like molecules as a model for peptide β-sheet tapes, ribbons, fibrils, and fibers [J].

Aggeli, A ;

Nyrkova, IA ;

Bell, M ;

Harding, R ;

Carrick, L ;

McLeish, TCB ;

Semenov, AN ;

Boden, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :11857-11862

[2]

[Anonymous], 2002, LIQUID CRYSTALS NATU

[3] Formation of short, stable helices in aqueous solution by β-amino acid hexamers [J].

Appella, DH ;

Barchi, JJ ;

Durell, SR ;

Gellman, SH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (10) :2309-2310

[4] The isolation and some properties of liquid crystalline substances from solanaceous plants infected with three strains of tobacco mosaic virus [J].

Bawden, FC ;

Pirie, NW .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1937, 123 (832) :274-320

[5] AROMATIC-AROMATIC INTERACTION - A MECHANISM OF PROTEIN-STRUCTURE STABILIZATION [J].

BURLEY, SK ;

PETSKO, GA .

SCIENCE, 1985, 229 (4708) :23-28

[6] Amyloid fibril formation can proceed from different conformations of a partially unfolded protein [J].

Calamai, M ;

Chiti, F ;

Dobson, CM .

BIOPHYSICAL JOURNAL, 2005, 89 (06) :4201-4210

[7] Compatibility of lyotropic liquid crystals with viruses and mammalian cells that support the replication of viruses [J].

Cheng, LL ;

Luk, YY ;

Murphy, CJ ;

Israel, BA ;

Abbott, NL .

BIOMATERIALS, 2005, 26 (34) :7173-7182

[8] β-peptides:: From structure to function [J].

Cheng, RP ;

Gellman, SH ;

DeGrado, WF .

CHEMICAL REVIEWS, 2001, 101 (10) :3219-3232

[9]

DIERKING I, TEXTURES LIQUID CRYS

[10] Protein folding and misfolding [J].

Dobson, CM .

NATURE, 2003, 426 (6968) :884-890

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