A novel three-component butenolide synthesis

被引：94

作者：

Beck, B

Magnin-Lachaux, M

Herdtweck, E

Dömling, A

机构：

[1] Morphochem AG, D-81379 Munich, Germany

[2] Univ Munich, Anorgan Chem Inst Tech, D-85747 Garching, Germany

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 18期

关键词：

D O I：

10.1021/ol016328u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 5-Acylamino butenolides can be assembled by a multicomponent reaction (MCR) of isocyanides, glyoxals, and acetophosphonic acid diethylesters, followed by a intramolecular Wittig-type reaction. The reaction can be performed either in one pot or with the isolation of the intermediate Passerini product. This versatile reaction offers three independent inputs displayed in the final product. Applications in combinatorial chemistry and natural product synthesis can be envisioned.

引用

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页码：2875 / 2878

页数：4

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