Messy biology and the origins of evolutionary innovations

被引：152

作者：

Tawfik, Dan S. ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 10期

关键词：

STOCHASTIC GENE-EXPRESSION; SINGLE-CELL; EVOLVABILITY; ENZYME; NOISE; ROBUSTNESS; SURVIVAL; NETWORKS; CHANCE; GENOME;

D O I：

10.1038/nchembio.441

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological messiness relates to infidelity, heterogeneity, stochastic noise and variation—both genetic and phenotypic—at all levels, from single proteins to organisms. Messiness comes from the complexity and evolutionary history of biological systems and from the high cost of accuracy. For better or for worse, messiness is inherent to biology. It also provides the raw material for physiological and evolutionary adaptations to new challenges.

引用

页码：692 / 696

页数：5

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