Functionalization of natural drimanic compounds via microbial/chemical tandem reactions

被引：7

作者：

Aranda, G ^{[1
]}

Bertranne-Delahaye, M

Lallemand, JY

Azerad, R

Maurs, M

Cortes, M

Lopez, J

机构：

[1] Ecole Polytech, Synth Organ Lab, URA 1308 CNRS, F-91128 Palaiseau, France

[2] Univ Paris 05, URA 400 CNRS, Chim & Biochim Pharmacol & Toxicol Lab, F-75006 Paris, France

[3] Pontificia Univ Catolica Chile, Fac Quim, Santiago, Chile

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1998年 / 5卷 / 1-4期

关键词：

terpenes; 3; beta-hydroxylation; 1; alpha-hydroxylation; polygodial; cinnamodial; warburganal; forskolin; scalaradial; Aspergillus niger;

D O I：

10.1016/S1381-1177(98)00035-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The direct microbial 3 beta-hydroxylation of drimanic terpenes by filamentous fungi, followed by a transfer of the functionalization from the 3 beta- to the 1 alpha-position has been used for preparing derivatives of antifeedant terpenic compounds bearing an additional 1 alpha-hydroxyl group. The semisynthesis of 1 alpha-hydroxypolygodial is described as an example. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：203 / 206

页数：4

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