Do most lymphocytes in humans really reside in the gut?

被引：162

作者：

Ganusov, Vitaly V. ^{[1
]}

De Boer, Rob J. ^{[1
]}

机构：

[1] Univ Utrecht, NL-3584 CH Utrecht, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 12期

关键词：

D O I：

10.1016/j.it.2007.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is widely believed that the gut, and particularly the lamina propria (LP) of the gut, contains most of the lymphocytes in humans. The strong depletion of CD4(+) T cells from the gut LP of HIV-infected patients was, therefore, suggested to be such a large, irreversible insult that it could explain HIV disease progression. However, reviewing data from different mammalian species, we found that only 5%-20% of all lymphocytes reside in the gut, and that only 1%-9% of the total lymphocyte number is located in the gut LP. Our findings suggest that spleen and lymph nodes, rather than the gut, are the largest immune compartments in mammals.

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收藏

页码：514 / 518

页数：5

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