Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

被引：204

作者：

Loeffler, DA

Lewitt, PA

Juneau, PL

Sima, AAF

Nguyen, HU

DeMaggio, AJ

Brickman, CM

Brewer, GJ

Dick, RD

Troyer, MD

Kanaley, L

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT NEUROL,DETROIT,MI 48201

[2] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,DETROIT,MI 48201

[3] WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201

[4] UNIV MICHIGAN,DEPT HUMAN GENET,ANN ARBOR,MI 48109

[5] BRIGHAM & WOMENS HOSP,HARVARD LONGWOOD NEUROL PROGRAM,BOSTON,MA 02115

[6] MCLEAN HOSP,HARVARD BRAIN TISSUE RESOURCE CTR,BELMONT,MA 02178

来源：

BRAIN RESEARCH | 1996年 / 738卷 / 02期

关键词：

acute phase protein; Alzheimer's disease; ceruloplasmin; copper; Huntington's disease; Parkinson's disease; progressive supranuclear palsy;

D O I：

10.1016/S0006-8993(96)00782-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD, n = 12), Parkinson's disease (PD, n = 14), Huntington's disease (HD, n = 11), progressive supranuclear palsy (PSP, n = 11), young adult normal controls (YC, n = 6) and elderly normal controls (EC, n = 7). Mean CP concentrations were significantly increased vs. EC (P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. Immunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress.

引用

页码：265 / 274

页数：10

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