DNA microarrays as decoding tools in combinatorial chemistry and chemical biology

被引：29

作者：

Lovrinovic, M ^{[1
]}

Niemeyer, CM ^{[1
]}

机构：

[1] Univ Dortmund, Fachbereich Chem Biol Chem Mikrostrukturtech, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 21期

关键词：

combinatorial chemistry; DNA; immobilization; microarrays; proteins;

D O I：

10.1002/anie.200500645

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Decoding technology: Besides mainstream applications in transcription profiling, DNA microarrays are currently being explored as tools for the deconvolution of synthetic libraries. Current examples include the discovery of a new type of organic reaction and the screening of peptide nucleic acid encoded inhibitor libraries to investigate new proteolytic activities from dust mite extracts (see picture). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3179 / 3183

页数：5

共 45 条

[1]

[Anonymous], ANGEW CHEM

[2] Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response [J].

Carroll, AS ;

Bishop, AC ;

DeRisi, JL ;

Shokat, KM ;

O'Shea, EK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) :12578-12583

[3]

Ceyhan B, 2001, ANGEW CHEM, V113, P3798

[4] Combinatorial libraries -: from solution to 2D microarrays [J].

Díaz-Mochón, JJ ;

Bialy, L ;

Keinicke, L ;

Bradley, M .

CHEMICAL COMMUNICATIONS, 2005, (11) :1384-1386

[5] Microarray-based in vitro evaluation of DNA oligomer libraries designed in silico [J].

Feldkamp, U ;

Wacker, R ;

Schroeder, H ;

Banzhaf, W ;

Niemeyer, CM .

CHEMPHYSCHEM, 2004, 5 (03) :367-372

[6] Covalent hemin-DNA adducts for generating a novel class of artificial heme enzymes [J].

Fruk, L ;

Niemeyer, CM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (17) :2603-2606

[7]

Fruk L., 2005, ANGEW CHEM, V117, P2659

[8] Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays [J].

Harris, J ;

Mason, DE ;

Li, J ;

Burdick, KW ;

Backes, BJ ;

Chen, T ;

Shipway, A ;

Van Heeke, G ;

Gough, L ;

Ghaemmaghami, A ;

Shakib, F ;

Debaene, F ;

Winssinger, N .

CHEMISTRY & BIOLOGY, 2004, 11 (10) :1361-1372

[9] Activity-based high-throughput screening of enzymes by using a DNA microarray [J].

Hu, Y ;

Chen, GYJ ;

Yao, SQ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (07) :1048-1053

[10]

HU Y, 2005, ANGEW CHEM, V117, P1072

← 1 2 3 4 5 →