Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia

被引：229

作者：

Blanco-Andujar, Cristina ^{[1
]}

Walter, Aurelie ^{[1
]}

Cotin, Geoffrey ^{[1
]}

Bordeianu, Catalina ^{[1
]}

Mertz, Damien ^{[1
]}

Felder-Flesch, Delphine ^{[1
]}

Begin-Colin, Sylvie ^{[1
]}

机构：

[1] UMR CNRS UdS 7504, IPCMS, 23 Rue Loess,BP 43, F-67034 Strasbourg 2, France

来源：

NANOMEDICINE | 2016年 / 11卷 / 14期

关键词：

iron oxide; magnetic hyperthermia; MRI; nanoparticles; CORE-SHELL NANOPARTICLES; CONTRAST AGENTS; FE3O4; NANOPARTICLES; HEATING EFFICIENCY; ABSORPTION RATE; EXCHANGE BIAS; PARTICLE-SIZE; CANCER; NANOCUBES; NANOCRYSTALS;

D O I：

10.2217/nnm-2016-5001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Iron oxide nanoparticles are widely used for biological applications thanks to their outstanding balance between magnetic properties, surface-to-volume ratio suitable for efficient functionalization and proven biocompatibility. Their development for MRI or magnetic particle hyperthermia concentrates much of the attention as these nanomaterials are already used within the health system as contrast agents and heating mediators. As such, the constant improvement and development for better and more reliable materials is of key importance. On this basis, this review aims to cover the rational design of iron oxide nanoparticles to be used as MRI contrast agents or heating mediators in magnetic hyperthermia, and reviews the state of the art of their use as nanomedicine tools.

引用

页码：1889 / 1910

页数：22

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