Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats

被引:33
作者
Arnelo, U [1 ]
Reidelberger, R
Adrian, TE
Larsson, J
Permert, J
机构
[1] Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA
[2] Huddinge Univ Hosp, Karolinska Inst, Dept Surg, Arvid Wretlind Lab Metab Res, S-14186 Huddinge, Sweden
[3] Dept Vet Affairs Med Ctr, Omaha, NE 68105 USA
关键词
amylin; appetite regulation; meal patterns; radioimmunoassay; threshold dose;
D O I
10.1152/ajpregu.1998.275.5.R1537
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Our objective was to study whether islet amyloid polypeptide (IAPP) produces satiety by an endocrine mechanism. We used a rat model to determine whether postprandial plasma levels of IAPP are comparable to those required to inhibit feeding when IAPP is administered by continuous intravenous infusion. Food intake in rats with aortic catheters increased plasma IAPP levels from a fasting level of 10.8 +/- 0.5 pM to a peak level of 19.0 +/- 1.0 pM at 2.2 +/- 0.5 h. in rats with jugular vein and aortic catheters, the threshold intravenous dose for IAPP suppression of feeding was between 1 and 3 pmol . kg(-1). min(-1). The 3 pmol . kg(-1). min(-1) dose decreased 4-h intake by similar to 25% by decreasing meal frequency rather than meal size. This dose increased plasma IAPP by similar to 24 pM. These results suggest that postprandial plasma levels of IAPP are not quite sufficient to independently produce satiety.
引用
收藏
页码:R1537 / R1542
页数:6
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