Transannular nitrone cycloaddition. A stereocontrolled entry to the spirocyclic core of pinnaic acid

被引：54

作者：

White, JD ^{[1
]}

Blakemore, PR ^{[1
]}

Korf, EA ^{[1
]}

Yokochi, AFT ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 03期

关键词：

D O I：

10.1021/ol000361j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Thermolysis of lactone 18 initiated a stereospecific transannular nitrone-olefin [3 + 2] cycloaddition to yield tetracycle 19, Methanolysis followed by reductive cleavage of the isoxazolidine yielded 20, representing the azaspirocyclic core of pinnaic acid (1).

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页码：413 / 415

页数：3

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