Synthesis of a 6-azaspiro[4.5]decane related to halichlorine and the pinnaic acids

被引:52
作者
Clive, DLJ [1 ]
Yeh, VSC [1 ]
机构
[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/S0040-4039(99)01815-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Sulfone 15, derived from D-glutamic acid, and aldehyde 23, made by diastereoselective alkylation, were linked and elaborated into enamine sulfone 33. This underwent 5-exo radical cyclization to 34, which was desulfonylated to (-)-35, a compound that represents the spirobicyclic core of halichlorine. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
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页码:8503 / 8507
页数:5
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