Synthesis of a 6-azaspiro[4.5]decane related to halichlorine and the pinnaic acids

被引：52

作者：

Clive, DLJ ^{[1
]}

Yeh, VSC ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(99)01815-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sulfone 15, derived from D-glutamic acid, and aldehyde 23, made by diastereoselective alkylation, were linked and elaborated into enamine sulfone 33. This underwent 5-exo radical cyclization to 34, which was desulfonylated to (-)-35, a compound that represents the spirobicyclic core of halichlorine. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8503 / 8507

页数：5

共 22 条

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