Synthesis of pinnaic acid; Asymmetric construction of spirocyclic core

被引：45

作者：

Arimoto, H ^{[1
]}

Asano, S

Uemura, D

机构：

[1] Shizuoka Univ, Fac Sci, Dept Chem, Ohya, Shizuoka 4228529, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 18期

关键词：

alkaloids; asymmetric synthesis; marine metabolites; spiro compounds;

D O I：

10.1016/S0040-4039(99)00578-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the spirocyclic core of pinnaic acid, a cPLA(2) inhibitor, is described. A key transformation in the sequence involves an asymmetric Michael-initiated ring closure. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3583 / 3586

页数：4

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