Multiple drug resistance due to resistance to stem cells and stem cell treatment progress in cancer

被引：61

作者：

Di, Chong ^{[1
]}

Zhao, Yaodong ^{[1
]}

机构：

[1] Tongji Univ, Dept Neurosurg, Shanghai Peoples Hosp 10, Sch Med, Shanghai 200072, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2015年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cancer stem cell; multiple drug resistance; adenosine triphosphate-binding cassette transporter; aldehydes dehydrogenase; microenvironment; epithelial to mesenchymal transition; ALDEHYDE DEHYDROGENASE ALDH; SIDE-POPULATION CELLS; MULTIDRUG-RESISTANCE; LUNG-CANCER; CHEMOTHERAPY; INHIBITION; CARCINOMA; PATHWAY; LINES; MICROENVIRONMENT;

D O I：

10.3892/etm.2014.2141

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

In recent years, the cancer stem cell.(CSC) theory has provided a new angle in the research of cancer, and has gradually gained significance. According to this theory, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs, and a significant quantity of research has been carried out into the MDR mechanisms of CSC. Over time, some of these mechanisms have been gradually accepted, including ATP-binding cassette transporters, aldehyde dehydrogenase, the CSC microenvironment and epithelial to mesenchymal transition. In the present review, we summarize these mechanisms in detail" and review possible appropriate therapy plans against CSCs based on CSC theory.

引用

页码：289 / 293

页数：5

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