Stereoselective synthesis of optically active pyridyl alcohols via asymmetric transfer hydrogenation of pyridyl ketones

被引：110

作者：

Okano, K

Murata, K

Ikariya, T

机构：

[1] Tokyo Inst Technol, CREST, Grad Sch Sci & Engn, Meguro Ku, Tokyo 1528552, Japan

[2] Mitsubishi Chem Corp, Tsukuba Res Ctr, Ami, Ibaraki 30003, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

关键词：

asymmetric transfer hydrogenation; formic acid; chiral Ru catalyst; acetylpyridine;

D O I：

10.1016/S0040-4039(00)01695-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral Ru(II) complex, RuCl[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenyl-ethylenediamine](p-cymene), serves as an efficient catalyst for asymmetric transfer hydrogenation of 2-acetylpyridine with a substrate to catalyst molar ratio of 200-1000 with HCOOH as a hydrogen source to give (S)-1-(2-pyridyl)ethanol in an almost quantitative yield and with 95% ee. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：9277 / 9280

页数：4

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