Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction

被引：104

作者：

Corey, EJ

Helal, CJ

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(96)01198-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new process has been developed for the highly enantioselective catalytic reduction of 2-aroylpyridines and successfully applied to the synthesis of (S)-carbinoxamine (1), a therapeutically important histamine H-1 antagonist. Related enantioselective reductions of 4-aroylpyridines and ortho-substituted benzophenones are also described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5675 / 5678

页数：4

共 38 条

[1]

BARNHART ER, 1990, PHYSICIANS DESK REFE, P1898

[2]

BAROUH V, 1971, J MED CHEM, V14, P834

[3]

BOJADZIEV SE, 1987, B CHEM SOC JPN, V60, P2651

[4]

BRAKER W, 1962, Patent No. 905993