The solid phase synthesis of complex propargylamines using the combination of Sonogashira and Mannich reactions

被引：93

作者：

Dyatkin, AB ^{[1
]}

Rivero, RA ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00639-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Sonogashira reaction of a resin-bound iodobenzoic acid with trimethylsilyl acetylene followed by TBAF desilylation provided a polymer-supported aryl acetylene, 3. Treatment of 3 with an aldehyde and a secondary amine in dioxane in the presence of CuCl catalyst results in the generation of resin-bound propargylamines. The final products (4) were cleaved from the resin and obtained in excellent yields and purity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3647 / 3650

页数：4

共 14 条

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