Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology

被引：84

作者：

McNally, JJ ^{[1
]}

Youngman, MA ^{[1
]}

Dax, SL ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

关键词：

D O I：

10.1016/S0040-4039(97)10716-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkynes, secondary amines and aldehydes, in the presence of a copper (I) salt, undergo Mannich reactions to afford the corresponding aminomethylalkynyl adducts on a solid support. Any member of this three-component reaction system can be immobilized on a resin providing three distinct routes for the generation of structurally diverse compound libraries. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：967 / 970

页数：4

共 8 条

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