Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+T cells that impacts organismal metabolism

被引：121

作者：

Cipolletta, Daniela ^{[1
]}

Kolodin, Dmitriy ^{[1
]}

Benoist, Christophe ^{[1
]}

Mathis, Diane ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

SEMINARS IN IMMUNOLOGY | 2011年 / 23卷 / 06期

基金：

美国国家科学基金会;

关键词：

Regulatory T cells; Obesity; Type; 2; diabetes; Inflammation; Adipose tissue; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; B-CELLS; MACROPHAGE RECRUITMENT; REGULATORY CELLS; INFLAMMATION; MICE; FAT; INDUCTION;

D O I：

10.1016/j.smim.2011.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Foxp3+CD4+ regulatory T (T-reg) cells are a key population in controlling the immune response. Recently, their roles have been expanded to broader, non-immune, contexts, in particular the metabolic consequences downstream of obesity-induced inflammation, e.g. type-2 diabetes and cardiovascular disease. This review highlights the major innate and adaptive immune cell subsets contributing to adipose-tissue inflammation, the key role played by fat-resident T-regs, and the potential of T-reg-based therapies for treatment of the metabolic syndrome. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：431 / 437

页数：7

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