Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells

被引：158

作者：

Myung, Ja Hye ^{[1
]}

Gajjar, Khyati A. ^{[1
]}

Saric, Jelena ^{[1
]}

Eddington, David T. ^{[1
]}

Hong, Seungpyo ^{[1
]}

机构：

[1] Univ Illinois, Dept Bioengn, Dept Biopharmaceut Sci, Chicago, IL 60612 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 49期

基金：

美国国家科学基金会;

关键词：

biomimetics; cell adhesion; dendrimers; multivalent binding; tumor cells; EFFICIENT CAPTURE; IMMOBILIZATION; FLOW;

D O I：

10.1002/anie.201105508

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A naturally occurring multivalent binding effect is manipulated by engineering cell capture surfaces using dendrimers. The enhanced binding through the multivalent effect significantly improves detection of tumor cells. This improvement can be potentially translated into clinically significant detection of circulating tumor cells from the blood of cancer patients. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11769 / 11772

页数：4

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