The mammalian Mediator complex and its role in transcriptional regulation

被引：236

作者：

Conaway, RC

Sato, S

Tomomori-Sato, C

Yao, TT

Conaway, JW ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 05期

关键词：

D O I：

10.1016/j.tibs.2005.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of > 20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

引用

页码：250 / 255

页数：6

共 59 条

[1] TFIIH is negatively regulated by cdk8-containing mediator complexes
Akoulitchev, S
Chuikov, S
Reinberg, D
[J]. NATURE, 2000, 407 (6800) : 102 - 106
[2] Transcriptional activating regions target a cyclin-dependent kinase
Ansari, AZ
Koh, SS
Zaman, Z
Bongards, C
Lehming, N
Young, RA
Ptashne, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) : 14706 - 14709
[3] Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
Boube, M
Joulia, L
Cribbs, DL
Bourbon, HM
[J]. CELL, 2002, 110 (02) : 143 - 151
[4] A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II
Bourbon, HM
Aguilera, A
Ansari, AZ
Asturias, FJ
Berk, AJ
Bjorklund, S
Blackwell, TK
Borggrefe, T
Carey, M
Carlson, M
Conaway, JW
Conaway, RC
Emmons, SW
Fondell, JD
Freedman, LP
Fukasawa, T
Gustafsson, CM
Han, M
He, X
Herman, PK
Hinnebusch, AG
Holmberg, S
Holstege, FC
Jaehning, JA
Kim, YJ
Kuras, L
Leutz, A
Lis, JT
Meisterernest, M
Naar, AM
Nasmyth, K
Parvin, JD
Ptashne, M
Reinberg, D
Ronne, H
Sadowski, I
Sakurai, H
Sipiczki, M
Sternberg, PW
Stillman, DJ
Strich, R
Struhl, K
Svejstrup, JQ
Tuck, S
Winston, F
Roeder, RG
Kornberg, RD
[J]. MOLECULAR CELL, 2004, 14 (05) : 553 - 557
[5] Mammalian Srb Mediator complex is targeted by adenovirus E1A protein
Boyer, TG
Martin, MED
Lees, E
Ricciardi, RP
Berk, AJ
[J]. NATURE, 1999, 399 (6733) : 276 - 279
[6] Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
Brower, CS
Sato, S
Tomomori-Sato, C
Kamura, T
Pause, A
Stearman, R
Klausner, RD
Malik, S
Lane, WS
Sorokina, I
Roeder, RG
Conaway, JW
Conaway, RC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) : 10353 - 10358
[7] Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA
Cantin, GT
Stevens, JL
Berk, AJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) : 12003 - 12008
[8] Genetics of transcriptional regulation in yeast: Connections to the RNA polymerase II CTD
Carlson, M
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 : 1 - 23
[9] Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
Chi, Y
Huddleston, MJ
Zhang, XL
Young, RA
Annan, RS
Carr, SA
Deshaies, RJ
[J]. GENES & DEVELOPMENT, 2001, 15 (09) : 1078 - 1092
[10] MECHANISM OF PROMOTER SELECTION BY RNA POLYMERASE-II - MAMMALIAN TRANSCRIPTION FACTORS ALPHA AND BETA-GAMMA PROMOTE ENTRY OF POLYMERASE INTO THE PREINITIATION COMPLEX
CONAWAY, RC
GARRETT, KP
HANLEY, JP
CONAWAY, JW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) : 6205 - 6209

← 1 2 3 4 5 6 →