Chemical genetics: catalysing pathway exploration and new target discovery

被引:3
作者
Armstrong, Joshua I. [1 ]
机构
[1] Mendel Biotechnol Inc, Hayward, CA 94542 USA
关键词
chemical genetics; hormone signaling; growth regulator;
D O I
10.1002/jsfa.2967
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Chemical genetics couples the availability of diverse chemistry with the strengths of molecular genetics to dissect signalling pathways in complex organisms. Plant biology laboratories have integrated this approach into their repertoire for probing hormone signalling, physiology and pesticide mode of action. These studies have led to the discovery of compounds that regulate development and the response to environmental stress. Chemical genetics facilitates our understanding of genetic signalling pathways and offers a new approach to pest management and plant health by enabling the direct chemical modulation of plant defence signalling. (c) 2007 Society of Chemical Industry
引用
收藏
页码:1985 / 1990
页数:6
相关论文
共 36 条
[31]   The brassinosteroid signal transduction pathway [J].
Wang, Zhi-Yong ;
Wang, Qiaomei ;
Chong, Kang ;
Wang, Fengru ;
Wang, Lei ;
Bai, Mingyi ;
Jia, Chengguo .
CELL RESEARCH, 2006, 16 (05) :427-434
[32]   Characterization of terfestatin A, a new specific inhibitor for auxin signaling [J].
Yamazoe, A ;
Hayashi, K ;
Kepinski, S ;
Leyser, O ;
Nozaki, H .
PLANT PHYSIOLOGY, 2005, 139 (02) :779-789
[33]   BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation [J].
Yin, YH ;
Wang, ZY ;
Mora-Garcia, S ;
Li, JM ;
Yoshida, S ;
Asami, T ;
Chory, J .
CELL, 2002, 109 (02) :181-191
[34]   SIR1, an upstream component in auxin signaling identified by chemical genetics [J].
Zhao, YD ;
Dai, XH ;
Blackwell, HE ;
Schreiber, SL ;
Chory, J .
SCIENCE, 2003, 301 (5636) :1107-1110
[35]   Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis [J].
Zheng, Wenguang ;
Zhai, Qingzhe ;
Sun, Jiaqiang ;
Li, Chang-Bao ;
Zhang, Lei ;
Li, Hongmei ;
Zhang, Xiaoli ;
Li, Shuyu ;
Xu, Yingxiu ;
Jiang, Hongling ;
Wu, Xiaoyan ;
Li, Chuanyou .
PLANT PHYSIOLOGY, 2006, 141 (04) :1400-1413
[36]   Sorting inhibitors (Sortins):: Chemical compounds to study vacuolar sorting in Arabidopsis [J].
Zouhar, J ;
Hicks, GR ;
Raikhel, NV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (25) :9497-9501