Identification of blood microRNAs associated to Parkinsonis disease

被引：207

作者：

Margis, Regina ^{[2
,3
]}

Margis, Rogerio ^{[1
,3
]}

Rieder, Carlos R. M. ^{[2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotechnol, Av Bento Goncalves 9500,Predio 43431,Sala 213,CxP, BR-91501970 Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Neurol Sect, Movement Disorders Unit, BR-9003500 Porto Alegre, RS, Brazil

[3] VITATEC Cons Des Biotecnol Ltda, BR-91010005 Porto Alegre, RS, Brazil

来源：

JOURNAL OF BIOTECHNOLOGY | 2011年 / 152卷 / 03期

关键词：

Parkinson's disease; MicroRNA; Neurodegenerative disease; RT-qPCR; Molecular marker; MINI-MENTAL-STATE; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISEASES; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; PROTEIN TPPP/P25; GENE-EXPRESSION; BRAIN; MECHANISM; TARGETS;

D O I：

10.1016/j.jbiotec.2011.01.023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：96 / 101

页数：6

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[31] Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies [J].